DISEASES RELATED TO CELL CYCLE DISORDER - MEDICINE - 2025

The diseases related disorder the cell cycle are more common than it seems and although perhaps many people around us, acquaintances and others, can suffer it and bear it, ignore it really that pathology is encouraged by the disorder of the cell cycle.

According to studies, the most common types of diseases related to cell cycle disorders are breast cancer, lung cancer, liver cancer, colon cancer, and leukemia.

On a large scale, the cell cycle is a set of steps that follow one another and whose main purpose and objective are to make each cell grow, as well as favor its reproduction and its division to start an endless cycle.

The cycle begins when a new cell appears, the product of the division of another cell, and the cycle concludes or ends when it is ready to divide.

Depending on its type, size and location, the cell may take more or less time to complete and carry out its entire cycle and function. Cells are the fundamental unit in our body and therefore directly influence the proper functioning of the body.

The role of cells and related diseases

The cells help to regenerate the tissues of each organ and to remove what has already died and fulfilled its function. Carrying oxygen, absorbing nutrients, and sending electrical signals are some of the main functions carried out by cells. Our growth and development depend on them.

This is why, if our cell cycle does not work properly, our body becomes sick and various organs begin to fail and cause problems. Generally, the most common disease caused by cell cycle disorder is cancer.

Actually, there is no disease that bears this name and the real problem that occurs with the body is that the cell cycle is not working properly.

Depending on the type of cell that does not reproduce properly, the disease or the organ that fails is different.

Most of the time, the process that happens is that the cells begin to reproduce rapidly, invading normal tissues and organs and the excess of them can be highly harmful. This is why malignant tumors arise.

List of diseases related to the cell cycle

1- Breast cancer

It is one of the diseases related to the most common cell cycle disorder and is considered the main cause of death in women (they are the main affected, with very few cases in men).

This pathology spreads when the cells located in the breast grow in an accelerated way and without any type of control. This is what causes the tumor and the lump that usually accompanies cancer.

The real problem occurs if these extra and unnecessary cells start to invade the breast tissue. If the spread of cells continues, it could affect other circumcising tissues or the rest of the body, causing metastasis.

2- Lung cancer

This is the cancer that affects a greater percentage of people in the world. The reason is due to the accelerated and uncontrolled growth of cells in the respiratory tract.

Generally, for many years, these cells have received certain stimuli (carcinogen) that have made them grow rapidly, causing the appearance of a tumor or neoplasm.

A tumor is considered malignant (and this is called cancer) if it acts aggressively and suppresses the tissues near it and, in turn, spreads to other places.

A carcinogen that can cause, worsen, or accelerate the development of this cancer is cigarette or tobacco smoking. Various studies have shown that both this smoke and environmental pollution contribute to the accelerated growth of "malignant cells".

3- Liver cancer

This is considered one of the most dangerous and harmful cancers that a person can suffer. Because the liver is the second most important organ in the human body (after the heart), people with this disease can barely survive for a few months.

As with lung cancer, cells begin to grow rapidly in liver tissues under the influence of external stimuli, such as excessive consumption of alcoholic beverages.

It is important to mention that the disease progresses because the DNA of the cells presents problems or is damaged and this prevents the correct functioning and reproduction of the cells.

Basically, cells never die and are left in the body without any function or purpose, wreaking havoc and damage to tissues, in this case, the liver.

4- Colon cancer

Generally, colon cancer appears and is identified thanks to the appearance of tumors in the large intestine, rectum or the colon itself.

Unlike other cancers, this is one that affects both men and women to the same extent and sex does not affect the acquisition of the disease in any way.

What can influence and contribute to the appearance of cancer in the colon is age. People over 50 years of age are more likely to suffer from it, especially if they lead an unhealthy lifestyle and an unbalanced diet.

5- Leukemia

Leukemia is one of the strangest cases related to cell cycle disorder.

This disease occurs in the bone marrow, which is responsible for producing white blood cells (agents used to fight diseases and infections) and mainly, disease and cancer occur when the bone marrow produces too many white blood cells.

The problem is that as the body is full of white blood cells, it prevents the production of red blood cells, platelets and leukocytes; which are also completely necessary for the proper functioning of the body.

This cancer can also be carried to other parts of the body, affecting different organs at the same time.

References

1. Agudelo, MPM, Botero, FEG, Buitrago, ICR, Noreña, GG, & Duque, JU (1995). Breast cancer Colombian Journal of Obstetrics and Gynecology, 46 (2), 124-129. Recovered from: revista.fecolsog.org.
2. Evan, GI, & Vousden, KH (2001). Proliferation, cell cycle and apoptosis in cancer. nature, 411 (6835), 342. Recovered from: search.proquest.com.
3. Hartwell, L. (1992). Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell, 71 (4), 543-546. Recovered from: sciencedirect.com.
4. Hartwell, LH, & Kastan, MB (1994). Cell cycle control and cancer. Science-AAAS-Weekly Paper Edition, 266 (5192), 1821-1828. Recovered from: jstor.org.
5. Maluales, M., & Barbacid, M. (2009). Cell cycle, CDKs and cancer: a changing paradigm. Nature reviews. Cancer, 9 (3), 153. Recovered from: search.proquest.com.
6. Sánchez Socarrás, V. (2001). Regulatory mechanisms of non-necrotic cell death. Cuban Journal of Biomedical Research, 20 (4), 266-274. Recovered from: scielo.sld.cu.
7. Spiegel, D., Kraemer, H., Bloom, J., & Gottheil, E. (1989). Effect of psychosocial.treatment on survival of patients with metastatic breast cancer. The Lancet, 334 (8668), 888-891. Recovered from: sciencedirect.com.